The new interfaces are changing the way we interact with computers. In the musical context, those new technologies open a wide range of possibilities in the creation of New Interfaces for Musical Expression (NIME). Despite 10 years of research in NIME, it is hard to find artifacts that have been widely or convincingly adopted by musicians. In this paper, we discuss some NIME design challenges, highlighting particularities related to the digital and musical nature of these artifacts, such as virtuosity, cultural elements, context of use, creation catalysis, success criteria, adoption strategy, etc. With these challenges, we aim to call attention for the intersection of music, computing and design, which can be an interesting area for people working on product design and in-teraction design.